Drug intelligence / Profile preview

Bovine Basic Gel

Development stage
Unknown
Lead developer
Zhuhai Essex Bio-Pharmaceutical
Modality
Hydrogel Systems → Drug Delivery Systems
Administration
Topical
01

Overview

Bovine Basic Gel is an inert topical vehicle formulation used as a placebo control in clinical trials, specifically in studies evaluating recombinant bovine basic fibroblast growth factor (rbFGF) gel. It is utilized in a randomized, double-blind, half-face controlled trial (NCT06516939) sponsored by Shanghai Dermatology Hospital to treat sensitive skin with persistent erythema. As a vehicle control, it lacks the active bFGF protein, which is a mitogenic polypeptide that promotes skin repair by binding to fibroblast growth factor receptors (FGFRs). The gel serves to establish a baseline for efficacy and safety comparisons against the active rbFGF treatment.

Other names
vehicle gelbase gel
02

Targets

FGFR4 (Fibroblast growth factor receptor 4)FGFR-KLB complex (Fibroblast growth factor receptor 1c / beta-Klotho complex)FGFR3cHSPG (Basement membrane-specific heparan sulfate proteoglycan core protein (perlecan))FGFR2c (Fibroblast growth factor receptor 2 isoform IIIc)

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