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Bovine FSH superagonist is a recombinant protein analog of follicle-stimulating hormone (FSH) designed to activate the follicle-stimulating hormone receptor (FSHR) with enhanced potency and prolonged biological activity compared to standard pituitary-derived or recombinant FSH preparations. Developed by Trophogen and licensed to Zoetis for veterinary applications, the drug utilizes superagonist technology to stimulate ovarian follicular development and superovulation. It is being investigated for use in human reproductive medicine to treat infertility and in veterinary medicine to improve the efficiency of embryo transfer protocols in beef and dairy cattle. The molecule is engineered to have increased binding affinity and signaling efficacy at the FSH receptor, potentially allowing for reduced dosing frequency and improved clinical outcomes in assisted reproductive technologies.
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