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Bovine gelatin is a protein-based substance derived from the collagen of cattle, widely used in the pharmaceutical industry to manufacture hard and soft capsule shells. In the context of clinical research at the University of Virginia, specifically the SADFAT trial (NCT00543842), bovine gelatin capsules were utilized as a placebo control. This randomized controlled trial aimed to determine if the addition of omega-3 fatty acids (eicosapentaenoic acid and docosahexaenoic acid) to standard antidepressant regimens could accelerate the onset of clinical improvement in patients diagnosed with major depressive disorder. The gelatin capsules served as an inert comparator, matched in appearance to the active fish oil supplements to maintain the integrity of the double-blind study.
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