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BOX202-1

Development stage: Unknown
Lead developer: Bostal Pharma
Modality: Small Molecules
Administration: Subcutaneous

Overview

BOX202-1 is a once-monthly (1M) long-acting injectable (LAI) formulation of brexpiprazole, developed by Bostal Pharma (Bostal Drug Delivery) using its proprietary in-situ gel-forming depot technology (Geleepot®). Brexpiprazole is an atypical antipsychotic that acts as a partial agonist at dopamine D2 and serotonin 5-HT1A receptors, and as an antagonist at serotonin 5-HT2A receptors. BOX202-1 is designed to improve treatment adherence and provide sustained symptom control in patients with schizophrenia and agitation associated with dementia due to Alzheimer's disease. It is currently in Phase 2/3 clinical development.

Other names: Brexpiprazole LAI 1MBrexpiprazole long-acting injectable (1-month formulation)Brexpiprazole once-monthly long-acting formulationepiliprazole gelepiprazole gel依匹哌唑凝胶

Targets

HTR2A (Serotonin receptor 5-HT2A)HTR1A (Serotonin receptor 1A (5-hydroxytryptamine receptor 1A))DRD2 (Dopamine D2 Receptor)

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