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Bozatinix
- Development stage
- Unknown
- Lead developer
- Exelixis
- Modality
- Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Allosteric Modulators → Classical Binding Small Molecules → Small Molecules, Irreversible Covalent Inhibitors → Covalent Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Bozatinix is an oral, small molecule multi-kinase inhibitor containing the active pharmaceutical ingredient cabozantinib. Developed and marketed by Laboratorio Varifarma in Argentina, it functions as a tyrosine kinase inhibitor targeting several pathways including MET, VEGFR2, AXL, and RET. By inhibiting these kinases, the drug suppresses tumor cell proliferation, migration, and angiogenesis. Bozatinix is primarily indicated for the treatment of advanced renal cell carcinoma (RCC) and as a monotherapy for hepatocellular carcinoma (HCC) in adult patients who have previously received treatment with sorafenib.
- Brand names
- Bozatinix
- Other names
- cabozantinib
02
Targets
NTRK2 (Tropomyosin-related kinase receptor type B)AXL (AXL receptor tyrosine kinase)MET (Mesenchymal-epithelial transition factor receptor)ER-XVEGFR2 (Vascular endothelial growth factor receptor 2)ROS1 (Proto-oncogene tyrosine-protein kinase ROS)KIT (c-KIT proto-oncogene receptor tyrosine kinase)VEGFR-1 (Vascular endothelial growth factor receptor 1)TEK (Tie2)VEGFR3 (Vascular endothelial growth factor receptor 3)RET (Rearranged during transfection receptor tyrosine kinase)FLT3 (Fms related receptor tyrosine kinase 3)
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