bph-629

BPH‑629 is a synthetic small molecule belonging to the class of bisphosphonates and phenylbenzofurans[6][2]. It features two phosphonic acid groups attached to a hydroxy-substituted ethane backbone with a dibenzofuran-containing aromatic substituent. Bisphosphonates are primarily known for their ability to inhibit bone resorption by targeting osteoclasts; however, BPH‑629 has been studied as an inhibitor of geranylgeranyl pyrophosphate synthase (GGPPS), an enzyme involved in the mevalonate pathway critical for protein prenylation and cell signaling[2]. This mechanism suggests potential applications in bone disorders or diseases involving dysregulated protein prenylation.

Other names

2-(3-dibenzofuran-4-yl-phenyl)-1-hydroxy-1-phosphono-ethyl]-phosphonic acid(2-(3-dibenzofuran-4-yl-phenyl)-1-hydroxy-1-phosphono-ethyl)-phosphonic acid(1-hydroxy-2-(3-(8-oxatricyclo[7.4.0.02,7]trideca‑1(9),2(7),3,5,10,12-hexaen‑6‑yl)phenyl)-1-phosphonoethyl)phosphonic acid