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BPI-9016M

Development stage: Phase 1
Lead developer: Betta Pharmaceuticals
Modality: Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Allosteric Modulators → Classical Binding Small Molecules → Small Molecules, Irreversible Covalent Inhibitors → Covalent Small Molecules → Small Molecules
Administration: Oral

Overview

BPI-9016M is a novel, orally active small molecule tyrosine kinase inhibitor that selectively targets both c-MET and AXL receptor tyrosine kinases. By binding to these targets, BPI-9016M disrupts c-MET and AXL-mediated signaling pathways, leading to inhibition of tumor cell growth, migration, and invasion in cancers with overexpression or dysregulation of these kinases. It is being developed by Betta Pharmaceuticals for advanced non-small cell lung cancer (NSCLC), particularly in patients with c-MET overexpression or MET exon 14 skipping mutations.

Targets

AXL (AXL receptor tyrosine kinase)MET (Mesenchymal-epithelial transition factor receptor)

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