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BPI-9203
- Development stage
- Preclinical
- Lead developer
- Beta Pharma
- Modality
- Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics, Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
BPI-9203 is a bispecific monoclonal antibody being developed by Beta Pharma. It is designed to simultaneously target CD47 and Programmed Death-Ligand 1 (PD-L1). CD47 is a cell surface protein that acts as a "don't eat me" signal, allowing cancer cells to evade phagocytosis by macrophages. PD-L1 is an immune checkpoint protein that binds to PD-1 on T-cells to suppress the adaptive immune response. By blocking both CD47 and PD-L1, BPI-9203 aims to enhance both innate and adaptive antitumor immunity, potentially offering a synergistic therapeutic effect in the treatment of solid tumors.
- Other names
- BPI-9203-Beta Pharma-CD47-PD-L1-monoclonal antibodyBPI9203-Beta Pharma-CD47-PD-L1-monoclonal antibodyBPI 9203-Beta Pharma-CD47-PD-L1-monoclonal antibody
02
Targets
CD47 (Cluster of Differentiation 47)
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