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BPI-9206
- Development stage
- Preclinical
- Lead developer
- Beta Pharma
- Modality
- Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics, Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
BPI-9206 is a bispecific monoclonal antibody developed by Beta Pharma that simultaneously targets CD47 and Programmed Death-Ligand 1 (PD-L1). CD47 is a cell surface protein that acts as a "don't eat me" signal, allowing cancer cells to evade phagocytosis by macrophages. PD-L1 is a well-characterized immune checkpoint that suppresses T-cell activation. By blocking both CD47 and PD-L1, BPI-9206 is designed to synergistically activate both the innate and adaptive immune systems to recognize and eliminate tumor cells. It is currently in early-stage development for the treatment of solid tumors.
- Other names
- BPI-9206-Beta Pharma-CD47-PD-L1-monoclonal antibodyBPI9206-Beta Pharma-CD47-PD-L1-monoclonal antibodyBPI 9206-Beta Pharma-CD47-PD-L1-monoclonal antibody
02
Targets
CD47 (Cluster of Differentiation 47)CD274 (Programmed cell death protein 1 ligand 1)
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