Drug intelligence / Profile preview

BPM31510-Oral

Development stage
Phase 1
Lead developer
Berg
Modality
Small Molecules, Liposomes → Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
Administration
Oral
01

Overview

BPM31510-Oral is an investigational oral formulation of ubidecarenone (coenzyme Q10) developed as a lipid-drug conjugate nanodispersion. It is designed to deliver supraphysiological concentrations of ubidecarenone to target mitochondrial dysfunction in cancer and rare diseases. The drug works by correcting cancer cell metabolism, reactivating apoptosis, and modulating mitochondrial oxidative phosphorylation. This leads to increased production of mitochondrial superoxide and induction of cell death in tumor cells while preserving normal tissue function. BPM31510 has demonstrated potential benefits in glioblastoma multiforme (GBM), pancreatic cancer, epidermolysis bullosa (EB), primary CoQ10 deficiency, and other solid tumors[4][5][9][10].

Other names
ubidecarenone oral formulationoral BPM31510
02

Targets

OXPHOS (Mitochondrial OXPHOS complexes)

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