BPV10NO-Seoul Medical Center

BPV10NO-Seoul Medical Center refers to a specific experimental arm in a clinical trial conducted by Seoul Medical Center, evaluating the use of 10 mg of intrathecal hyperbaric bupivacaine in non-obese patients (BMI < 27.5 kg/m²). Bupivacaine is a potent, long-acting local anesthetic of the amide class. Its primary mechanism of action involves the reversible blockade of voltage-gated sodium channels in nerve fibers, which prevents the influx of sodium ions necessary for the initiation and conduction of action potentials. This results in a loss of sensation and motor function in the area served by the affected nerves. In the context of this study, it is used to provide spinal anesthesia for patients undergoing total knee replacement arthroplasty, with the goal of determining how body mass index affects the drug's median effective dose (ED50). The 'NO' in the code name likely designates the 'Non-Obese' patient group.

Other names

intrathecal bupivacaine 10 mg