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BQ7812
- Development stage
- Preclinical
- Lead developer
- V.A. Almazov Federal Center for Heart, Blood and Endocrinology
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Peptides
- Administration
- Intravenous
01
Overview
BQ7812 is a heterodimeric radiotracer designed for molecular imaging of prostate cancer. It consists of a urea-based prostate-specific membrane antigen (PSMA) inhibitor and a gastrin-releasing peptide receptor (GRPR) antagonist (RM26) connected via a linker and conjugated to a NOTA chelator. BQ7812 can be radiolabeled with isotopes such as gallium-68 ($^{68}\text{Ga}$) for positron emission tomography (PET) imaging or indium-111 ($^{111}\text{In}$) for single-photon emission computed tomography (SPECT) imaging. By simultaneously targeting both PSMA and GRPR, BQ7812 aims to overcome the limitations of heterogeneous target expression in prostate cancer lesions, improving diagnostic sensitivity and staging accuracy.
- Other names
- [111In]In-BQ7812[68Ga]Ga-BQ781268Ga-BQ7812gallium-68 BQ7812gallium68 BQ7812gallium 68 BQ7812indium-111 BQ7812indium111 BQ7812indium 111 BQ7812
02
Targets
GRPR (Gastrin-releasing peptide receptor)PSMA (Prostate-specific membrane antigen)
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