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BRAF V600E-pulsed DC1 vaccine
- Development stage
- Preclinical
- Lead developer
- Elicio Therapeutics
- Modality
- Dendritic Cell Vaccines → Immune Effector Cells → Other Cell Types → Cell Therapies, Vaccines & Immunotherapeutics
- Administration
- Injection
01
Overview
The BRAF V600E-pulsed DC1 vaccine is an experimental autologous cancer immunotherapy designed to treat melanomas harboring the BRAF V600E mutation. The vaccine utilizes Type 1-polarized dendritic cells (DC1), which are specialized antigen-presenting cells optimized to induce potent Th1-type immunity and activate cytotoxic CD8+ T-lymphocytes. These DC1 cells are loaded (pulsed) with an affinity-modified peptide derived from the mutated BRAF V600E oncoprotein. Upon administration, the vaccine presents this specific mutant peptide to the patient's immune system, training CD8+ T-cells to recognize and selectively eliminate cancer cells expressing the BRAF V600E mutation. Preclinical studies in murine melanoma models have demonstrated that this approach can induce robust oncogene-specific immune responses, leading to delayed tumor growth and improved survival.
- Other names
- BRAF(V600E)-pulsed DC1 vaccineBRAF V600E-pulsed Type 1-polarized dendritic cell vaccine
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