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BrainDos semaglutide is a preclinical intranasal, brain-targeted formulation of semaglutide being developed by Mattern Pharma using its proprietary BrainDos drug-delivery platform. The product is a peptide GLP-1 receptor agonist formulated in an oil-based intranasal system designed to bypass the blood-brain barrier, increase central nervous system exposure, and reduce systemic exposure relative to conventional delivery. Reported platform details indicate a thixotropic oleogel formulation with mucoadhesive nasal retention properties, intended primarily for obesity and related brain-targeted GLP-1 therapy, with potential broader relevance to disorders involving chronic brain inflammation.
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