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Drug intelligence / Profile preview
BrainDos tirzepatide
- Development stage
- Preclinical
- Lead developer
- MetP Pharma
- Modality
- Peptides, Inhalation Devices → Device-based Delivery → Drug Delivery Systems
- Administration
- Intranasal
01
Overview
BrainDos tirzepatide is a preclinical intranasal, brain-targeted formulation of tirzepatide being developed by Mattern Pharma for obesity and weight management. It uses the company's BrainDos nose-to-brain delivery platform, an oil-based thixotropic oleogel formulation designed to bypass the blood-brain barrier and enhance delivery to the central nervous system. The active pharmaceutical ingredient is tirzepatide, a dual agonist of the glucagon-like peptide 1 receptor and glucose-dependent insulinotropic polypeptide receptor, formulated as a peptide biologic for intranasal administration via a mono-dose applicator. Based on the provided company pipeline and news context, the program is in preclinical development, with reported preclinical findings suggesting enhanced central anti-inflammatory activity relative to aqueous tirzepatide solution.
- Brand names
- BrainDos
- Other names
- intranasal tirzepatideBrainDos tirzepatideBrainDos intranasal tirzepatidetirzepatide
02
Targets
GLP1R (GLP-1R)GIPR (Gastric inhibitory polypeptide receptor)
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