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brazilian green propolis extract (Instituto D’Or de Pesquisa e Ensino)

Development stage: Unknown
Lead developer: Instituto D’Or de Pesquisa e Ensino
Modality: Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration: Oral

Overview

Brazilian green propolis extract, specifically the standardized EPP-AF formulation, is a botanical product derived from the resin collected by honeybees (*Apis mellifera*) from the *Baccharis dracunculifolia* plant in Brazil. It is characterized by a high concentration of bioactive phenolic compounds, most notably artepillin C and various flavonoids. In clinical research, particularly the BeeCovid trials led by the D'Or Institute for Education and Research, it is being evaluated as an adjunct treatment for hospitalized COVID-19 patients. The extract is hypothesized to exert therapeutic effects through immunomodulatory and anti-inflammatory mechanisms, potentially mitigating the cytokine storm by inhibiting pathways such as PAK1 and NF-kappaB. Additionally, it has demonstrated potential antiviral properties by interfering with viral entry and replication targets.

Other names: Standardized Brazilian Green Propolis ExtractBeeCovid2BeeCovid-2BeeCovid 2

Targets

ACE2 (Angiotensin-converting enzyme 2)PAK1 (p21-activated kinase 1)TMPRSS2 (Transmembrane protease serine 2)

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