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BRCA2 siRNA
- Development stage
- Unknown
- Modality
- Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Intratumoral
01
Overview
BRCA2 siRNA (short interfering RNA targeting breast cancer susceptibility gene 2) is a double-stranded RNA molecule designed to specifically knock down the expression of the BRCA2 gene. In research settings, it is widely used to study the effects of BRCA2 deficiency on DNA repair, genomic stability, and cellular sensitivity to DNA-damaging agents or PARP inhibitors. Preclinically, BRCA2 siRNA has been investigated as a therapeutic strategy to induce 'complementary lethality' in cancer cells, sensitizing them to chemotherapies (such as cisplatin) and radiotherapy by impairing homologous recombination repair.
- Other names
- BRCA2 small interfering RNABRCA-2 small interfering RNABRCA 2 small interfering RNAsiBRCA2siBRCA-2siBRCA 2
02
Targets
DDR (DNA damage response)
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