Drug intelligence / Profile preview

BreakVax

Development stage
Phase 2
Lead developer
BreakBio
Modality
Peptides, Vaccines & Immunotherapeutics
Administration
Subcutaneous
01

Overview

**BreakVax** is an investigational, individualized multi-peptide cancer vaccine developed by BreakBio. For each patient, tumor DNA/RNA profiling, mass-spectrometry-based immunopeptidomics, and AI/ML prioritization are used to select up to 30 patient-specific tumor antigens, including neoantigens and other tumor-associated antigens, for manufacture as a personalized peptide immunotherapy. The vaccine is intended to prime and expand antigen-specific antitumor T-cell responses and is being evaluated with vaccine adjuvants and separately administered anticancer therapies, including chemotherapy and PD-1 blockade, for advanced solid tumors. ([moomoo.com](https://www.moomoo.com/news/post/75175223/breakbio-the-third-player-in-personalized-drugs-enters-the-clinic?data_ticket=1787644728746013&level=3))

Other names
BreakVaxBreakVax ImmunoTreatment
02

Targets

pMHC (Peptide-MHC complex family)

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