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brenetafusp + bevacizumab
- Development stage
- Phase 2
- Lead developer
- Immunocore
- Modality
- T-cell Engagers → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics, Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics, Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
Brenetafusp is an ImmTAC (Immune mobilizing monoclonal TCRs Against Cancer) bispecific biologic targeting PRAME, under development for the treatment of ovarian cancer. It has shown clinical activity as monotherapy and in combination with chemotherapy in heavily pre-treated, platinum-resistant ovarian cancer patients. Bevacizumab is a recombinant humanized monoclonal antibody that inhibits vascular endothelial growth factor A (VEGF-A), thereby blocking angiogenesis and reducing tumor blood supply. Bevacizumab is approved for use in multiple cancers including colorectal, lung, glioblastoma, renal cell carcinoma, cervical cancer, and ovarian cancer. The combination of brenetafusp and bevacizumab represents a multi-modal approach targeting both tumor antigens (via T-cell redirection) and tumor vasculature (via VEGF inhibition)[3][4][5][7].
02
Targets
CD3 (T-cell surface glycoprotein CD3)HLA-A*02 (Human leukocyte antigen A*02 complexed peptide)VEGFA (Vascular endothelial growth factor A)PRAME (Preferentially expressed antigen in melanoma)
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