Drug intelligence / Profile preview

Breviprost

Development stage
Unknown
Lead developer
Liqvor
Modality
Small Molecules
Administration
Ophthalmic
01

Overview

Breviprost is a preservative-free ophthalmic formulation of travoprost, a synthetic prostaglandin F2α analogue, developed and manufactured by Liqvor. It is approved for the reduction of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension. As a selective agonist of the prostaglandin F receptor (PTGFR), travoprost lowers intraocular pressure by increasing the outflow of aqueous humor, primarily via the uveoscleral pathway. The preservative-free formulation of Breviprost is designed to minimize corneal toxicity, ocular irritation, and the development of dry eye syndrome, which are common with long-term use of preserved eye drops.

Brand names
Breviprost
Other names
Breviprost preservative-freetravoprost
02

Targets

PTGDR (Prostanoid DP1 receptor)PTGER1 (Prostaglandin E Receptor 1)PTGER3 (Prostaglandin E2 receptor EP3 subtype)PTGER4 (Prostaglandin E2 receptor EP4 subtype)PTGFR (Prostaglandin F2 alpha receptor)

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