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Bria-Lung
- Development stage
- Preclinical
- Lead developer
- BriaCell Therapeutics
- Modality
- Cell Therapies, Vaccines & Immunotherapeutics
- Administration
- Intradermal
01
Overview
Bria-Lung is an off-the-shelf, whole-cell immunotherapy being developed by BriaCell Therapeutics for the treatment of lung cancer. Based on the company's proprietary Bria-IMT™ platform, Bria-Lung consists of irradiated human lung cancer cells that have been genetically engineered to express multiple tumor antigens and secrete Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF). The therapy is designed to be HLA-matched to patients to optimize the stimulation of the immune system. Once administered, the secreted GM-CSF recruits and activates dendritic cells, which then internalize the tumor antigens from the Bria-Lung cells and present them to T cells, thereby inducing a potent and specific anti-tumor immune response against the patient's lung cancer.
- Brand names
- Bria-LUNG+
- Other names
- Bria-LUNG+
02
Targets
γδ TCR (T-cell receptor)MHC II (Major histocompatibility complex class II receptor)
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