brimonidine tartrate + timolol maleate

Brimonidine tartrate + timolol maleate is a fixed-dose combination ophthalmic solution used to reduce elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension who require adjunctive or replacement therapy. The medication combines two active ingredients with complementary mechanisms of action. Brimonidine is an alpha-2 adrenergic receptor agonist that decreases aqueous humor production and increases uveoscleral outflow, thereby lowering IOP. Timolol is a non-selective beta-adrenergic receptor antagonist (beta blocker) that reduces aqueous humor production in the ciliary body, also resulting in decreased IOP. This combination provides additive effects for lowering eye pressure and is typically administered as one drop to the affected eye(s) twice daily[1][2][5][6][8].

Brand names

Combigan

Other names

brimonidine/timolol ophthalmic solutionbrimonidine tartrate/timolol maleate ophthalmic solutionbrimonidine and timolol eye drops