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BRKB-20
- Development stage
- Preclinical
- Lead developer
- BrickBio
- Modality
- Cytotoxic ADCs → Antibody-Drug Conjugates (ADCs) → Antibody Conjugates → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
BRKB-20 is a preclinical-stage antibody-drug conjugate (ADC) being developed by BrickBio for the treatment of various oncology indications. The candidate is engineered using BrickBio's proprietary ETRNAL (Evolved tRNA Localization) platform, which enables site-specific bioconjugation of payloads to antibodies. BRKB-20 is part of the company's multi-payload ADC strategy, which involves the conjugation of multiple distinct payloads with synergistic mechanisms of action to a single antibody to enhance therapeutic efficacy and overcome resistance. While the specific molecular target remains undisclosed, the drug is designed to target solid tumors using a site-specific conjugation approach that ensures a homogeneous drug-to-antibody ratio (DAR).
- Other names
- BRKB-20-BrickBio-ADC-OncologyBRKB20-BrickBio-ADC-OncologyBRKB 20-BrickBio-ADC-Oncology
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