BRL54443

BRL54443 is a **synthetic small molecule** of the piperidinylindole class that acts as a **potent and selective agonist** at the serotonin **5-HT1E and 5-HT1F receptors**. It exhibits over 30-fold selectivity for these receptors compared to other 5-HT and dopamine receptor subtypes. In preclinical studies, BRL54443 has been shown to hyperpolarize neurons by increasing steady-state, depolarization-activated potassium currents, potentially involving voltage-gated potassium channels. It is primarily used as a research tool and is not approved for medical use. Its effects have been studied in behavioral and electrophysiological assays in animal models, including reduced locomotor activity in rats and dose-dependent actions on gastrointestinal function in cats[1][3][4][8].

Other names

3-(1-methylpiperidin-4-yl)-1H-indol-5-ol5-Hydroxy-3-(1-methylpiperidin-4-yl)-1H-indole