broadline

Broadline is a veterinary fixed-dose combination topical formulation containing fipronil, (S)-methoprene, eprinomectin, and praziquantel, used primarily for cats. It is indicated for the treatment and control of mixed infestations of ectoparasites—fleas, ticks, mites—and endoparasites, specifically gastrointestinal nematodes (hookworms, roundworms, lungworms, vesical worms) and cestodes (tapeworms) in cats. - **Fipronil** is a phenylpyrazole insecticide and acaricide acting as an adulticide by blocking ligand-gated chloride channels, particularly those gated by GABA and glutamate, leading to paralysis and death of parasites[7]. - **(S)-methoprene** is an insect growth regulator (IGR) with ovicidal and larvicidal activity, disrupting development by mimicking juvenile hormone and preventing maturation[7]. - **Eprinomectin** is an avermectin endectocide acting systemically against nematodes through high-affinity agonism of glutamate-gated chloride channels, leading to parasite paralysis and death[7]. - **Praziquantel** is a cestocide whose activity is primarily via increasing membrane permeability to calcium in tapeworms, resulting in muscular paralysis and tegumental disruption[7]. The combination provides broad-spectrum protection, including heartworm disease prevention and control of gastrointestinal parasites. It is administered topically as a spot-on solution and approved for use in cats. The product demonstrates high efficacy (>97–100%) against a wide range of feline parasites and is well tolerated[1][7].

Brand names

Broadline

Other names

fipronil + (S)-methoprene + eprinomectin + praziquantel