Drug intelligence / Profile preview

broadly neutralizing antibodies against enterovirus

Development stage
Preclinical
Lead developer
Amsterdam UMC
Modality
Monoclonal Antibodies → Antibody-Based Therapeutics
Administration
Parenteral
01

Overview

Broadly neutralizing antibodies (bNAbs) against enterovirus represent an early-stage immunotherapy research program initiated by the Academisch Medisch Centrum (AMC) in the Netherlands. The program focuses on the generation and development of antibody-based therapeutics capable of neutralizing a wide spectrum of enterovirus strains, which are responsible for diverse clinical manifestations including hand, foot and mouth disease, viral meningitis, and encephalitis. By targeting conserved epitopes across the enterovirus genus, these bNAbs aim to provide a versatile treatment option for systemic and severe viral infections where specific antiviral therapies are currently limited.

Other names
enterovirus immunotherapy program
02

Targets

EV-D68 capsid (Enterovirus D68 capsid protein)FCGRT (Neonatal crystallizable fragment receptor)Human Fc gamma receptors and complement component C1qNon-polio enterovirus capsid proteinVP2 (Infectious bursal disease virus VP2 protein)

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