bromisoval

Bromisoval is a small molecule hypnotic and sedative of the bromoureide group, first discovered by Knoll in 1907 and patented in 1909. It is primarily used for its tranquilizing and sleep-inducing properties, with actions similar to barbiturates and carbromal. Bromisoval acts as a positive allosteric modulator of the GABA_A receptor, enhancing the inhibitory effects of gamma-aminobutyric acid (GABA) in the central nervous system to produce sedation and hypnosis. It has also demonstrated anti-inflammatory effects by suppressing nitric oxide release and proinflammatory cytokine expression in activated macrophages. Bromisoval has been marketed over-the-counter in Asia under various trade names (such as Brovarin), often combined with nonsteroidal anti-inflammatory drugs. Chronic use can lead to bromine poisoning. Its clinical uses have included treatment of insomnia, pre-procedural sedation, anxiety relief, and inflammatory skin disorders[1][5][6][7][8].

Brand names

Brovarin

Other names

bromovalerylureaBU