bromo-willardiine

Bromo-willardiine is a synthetic analog of willardiine and belongs to the class of L-alpha-amino acids. It is characterized by a bromine atom at the 5-position of the uracil ring. Bromo-willardiine acts as a partial agonist at ionotropic glutamate receptors—specifically AMPA and kainate receptors—in the central nervous system. By binding to these receptors, it induces excitatory synaptic transmission via depolarization of neurons. The compound has been used extensively in neuropharmacological research to study receptor function and desensitization mechanisms. It is not approved for medical use and is primarily utilized as an experimental tool in neuroscience and peptide chemistry[1][5].

Other names

5-bromowillardiine2-amino-3-(5-bromo-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-propionic acid(S)-bromo-willardiine