Bromo-WR99210

Bromo-WR99210 is a synthetic small molecule and an analogue of the antimalarial agent WR99210. It acts as a potent inhibitor of dihydrofolate reductase (DHFR), an enzyme essential for DNA synthesis and cell survival in protozoan parasites such as Plasmodium falciparum and Mycobacterium tuberculosis. By inhibiting DHFR activity—crucial for the reduction of dihydrofolate to tetrahydrofolate—Bromo-WR99210 disrupts thymidylate and purine synthesis pathways required for nucleic acid production. This mechanism underlies its antiparasitic effects and makes it a valuable tool compound in research on drug-resistant malaria and tuberculosis[3][4][7]. The compound is not approved for clinical use but has been studied extensively in experimental settings.

Other names

1-(3-(4-bromophenoxy)propoxy)-6,6-dimethyl-1,6-dihydro-1,3,5-triazine-2,4-diamine1-[3-(4-bromophenoxy)propoxy]-6,6-dimethyl-1,6-dihydro-1,3,5-triazine-2,4-diamine179184-06-6