Drug intelligence / Profile preview

bromocriptine + octreotide

Development stage: Unknown
Lead developer: Novartis
Modality: Small Molecules, Peptides
Administration: Oral, Subcutaneous, Intramuscular

Overview

A combination therapy consisting of bromocriptine, a dopamine D2 receptor agonist, and octreotide, a somatostatin analog. This combination is primarily used for treating acromegaly and has been shown to reduce growth hormone (GH) and insulin-like growth factor-I (IGF-I) levels more effectively than either drug alone. The bioavailability of bromocriptine increases by approximately 40% when administered together with octreotide.

Targets

DRD2 (Dopamine D2 Receptor)SSTR2 (Somatostatin receptor type 2)SSTR5 (Somatostatin receptor 5)SSTR (Somatostatin receptors)

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