Drug intelligence / Profile preview

brompheniramine

Development stage
Approved
Modality
Small Molecules
Administration
Oral
01

Overview

Brompheniramine is a first-generation antihistamine of the alkylamine class used to relieve symptoms associated with allergies and the common cold such as sneezing, runny nose, itchy or watery eyes. It acts primarily as an antagonist (more accurately an inverse agonist) at histamine H1 receptor and also exhibits moderate antimuscarinic (anticholinergic) activity. This dual action helps reduce allergic symptoms but can cause side effects like drowsiness and dry mouth. Brompheniramine is typically administered orally and is well absorbed from the gastrointestinal tract. It was first approved in 1957 for medical use[1][2][3][5][7][8].

Brand names
Bromfed DMLodrane DM-end PEMar-cof BPSiltaneCophene BNasahist BRohistND-Stat
Other names
brompheniramine maleate
02

Targets

mAChR (Muscarinic acetylcholine receptors)HRH1 (Histamine H1 Receptor)

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