Drug intelligence / Profile preview

Bromus inermis pollen extract

Development stage
Unknown
Lead developer
ALK Abelló
Modality
Sublingual Immunotherapy → Allergy Immunotherapy → Therapeutic Vaccines → Vaccines & Immunotherapeutics, Subcutaneous Immunotherapy → Allergy Immunotherapy → Therapeutic Vaccines → Vaccines & Immunotherapeutics
Administration
Intradermal, Epicutaneous
01

Overview

Bromus inermis pollen extract, also known as smooth brome or brome grass pollen extract, is a biologic product used for allergen immunotherapy. Marketed by ALK-Abello, Inc. under the brand name CENTER-AL, it is formulated as an alum-precipitated therapeutic allergenic extract. [23] This preparation creates a depot effect, allowing for the slow release of the allergen and enhancing the immune response. It is administered via subcutaneous or intradermal injection to treat allergic conditions such as allergic rhinitis in patients with confirmed sensitivity to Bromus inermis pollen. The treatment involves a process of hyposensitization, where gradually increasing doses of the allergen are administered to induce immunological tolerance, aiming to shift the patient's immune response from an allergic (IgE-mediated) to a non-allergic state. Treatment is overseen by physicians experienced in allergen immunotherapy and is dosed based on individual patient sensitivity determined by skin testing. [23, 34]

Brand names
CENTER-AL
Other names
smooth brome pollen extractbrome grass pollen extractsmooth brome pollenbrome grass pollen
02

Targets

FCER1 (Fc epsilon RI receptor)

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