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Brotim
- Development stage
- Phase 4
- Lead developer
- AbbVie
- Modality
- Small Molecules
- Administration
- Ophthalmic, Topical
01
Overview
Brotim is a fixed-dose combination ophthalmic solution containing the alpha-2 adrenergic receptor agonist brimonidine and the non-selective beta-adrenergic receptor antagonist timolol. Developed by Optho Pharma, it is indicated for the reduction of elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension who require adjunctive or replacement therapy. Brimonidine works by reducing aqueous humor production and increasing uveoscleral outflow, while timolol decreases aqueous humor secretion. Together, these complementary mechanisms provide more effective IOP control than either agent alone.
- Brand names
- Brotim
- Other names
- brimonidine + timololbrimonidine tartrate + timolol maleatebrimonidine/timololtimolol + brimonidinetimolol maleate + brimonidine tartrate
02
Targets
ADRA2A (α2A)ADRA2B (α2B)ADRA2C (α2C)ADRB1 (β1)ADRB2 (β2)
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