Drug intelligence / Profile preview

Broussonetia papyrifera pollen

Development stage
Unknown
Lead developer
Jubilant HollisterStier
Modality
Recombinant Proteins and Enzymes
Administration
Inhalation, Intranasal, Intradermal, Ophthalmic, Topical
01

Overview

Broussonetia papyrifera pollen, derived from the Paper Mulberry tree, is a potent aeroallergen used clinically as an extract for the diagnosis of Type I hypersensitivity reactions, including allergic rhinitis, conjunctivitis, and asthma. The pollen contains several allergenic proteins, with Bro p 3 (a 10 kDa non-specific lipid transfer protein 1, nsLTP1) identified as a major allergen. Other identified allergenic components include proteins with molecular weights of 15 kDa, 33 kDa, 40 kDa, and 72 kDa. In diagnostic settings, the extract is used in skin prick testing (SPT) and in vitro assays to detect allergen-specific IgE. It demonstrates significant cross-reactivity with other Moraceae species (such as Morus alba) and Humulus scandens.

Other names
Paper mulberry pollenChinese mulberry pollen
02

Targets

IgE (Immunoglobulin E)

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