Drug intelligence / Profile preview

brown snake antivenom

Development stage
Unknown
Lead developer
CSL Seqirus
Modality
Antibody-Based Therapeutics
Administration
Intravenous
01

Overview

Brown snake antivenom is a purified equine-derived immunoglobulin (typically F(ab')2 fragments) used to treat envenomation by snakes of the genus *Pseudonaja* (brown snakes). The venom of these snakes is highly potent, primarily causing venom-induced consumptive coagulopathy (VICC) through the action of prothrombin activators, as well as neurotoxicity and occasionally nephrotoxicity. The antivenom works by binding to and neutralizing these circulating toxins. While specifically designed for *Pseudonaja* species, it has demonstrated clinical utility in treating envenomation by other species, such as the Pygmy Mulga snake (*Pseudechis pailsei*), due to cross-reactivity.

Brand names
Brown Snake Antivenom
Other names
Pseudonaja antivenom
02

Targets

svPLA2 (Snake venom phospholipase A2)SVSP (Snake venom serine protease)

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