BRP3

BRP3 (BRINP Related Peptide gene 3) is a novel 26-amino acid secreted anorexigenic peptide derived from the human weight-associated gene BRINP3 (bone morphogenetic protein/retinoic acid inducible neural specific 3). Identified through a peptide prediction algorithm mapping proprotein convertase (PCSK) cleavage sites, BRP3 is predominantly expressed in the paraventricular nucleus of the hypothalamus (PVH) and intestinal neurons. It circulates endogenously in both humans and mice. Pharmacological administration of BRP3 induces a rapid, dose-dependent suppression of food intake and weight loss in diet-induced obese and leptin-deficient models. Its mechanism of action involves the activation of discrete hypothalamic circuits, specifically increasing the firing rate of PVH neurons to drive non-aversive appetite suppression. Additionally, BRP3 appears to delay gastric emptying through peripheral mechanisms. Research indicates that its weight-reducing effects are additive with glucagon-like peptide-1 (GLP-1) receptor agonists, and it does not induce common side effects such as reduced locomotion or taste aversion.

Other names

BRINP Related Peptide gene 3BRINP3-derived peptideBRINP-3-derived peptideBRINP 3-derived peptide