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The Brucella abortus S19 vaccine is a live-attenuated bacterial vaccine used in veterinary medicine to prevent brucellosis, a significant zoonotic disease caused by the bacterium *Brucella abortus*. The vaccine is derived from the S19 strain, a stable, naturally occurring mutant that exhibits reduced virulence while maintaining high immunogenicity. It is primarily indicated for the vaccination of young female cattle and buffalo (typically between 3 to 8 months of age) to provide long-lasting protection against infection and associated reproductive failures such as abortion. The vaccine stimulates both humoral and cell-mediated immune responses. Indian Immunologicals is a major developer and manufacturer of this vaccine, marketing it under the brand name Bruvax as part of livestock health programs.
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