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Bryophyllum pinnatum crude leaf extract is a botanical preparation derived from the leaves of the *Bryophyllum pinnatum* plant (synonym *Kalanchoe pinnata*), a perennial herb widely used in traditional medicine across India, Africa, and tropical America. The extract is rich in bioactive phytochemicals, including flavonoids, triterpenoids, and bufadienolides (such as bryophyllin A and C). Research, including studies on human cervical cancer cells, indicates that the extract possesses significant anticancer and anti-Human Papillomavirus (HPV) properties. Its mechanism of action in oncology involves the induction of apoptosis and the downregulation of the viral oncoproteins E6 and E7, which are essential for maintaining the malignant phenotype in HPV-positive cancers. Traditionally, the extract has also been employed for its antimicrobial, anti-inflammatory, and wound-healing effects, as well as for treating bowel diseases and various infections.
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