Drug intelligence / Profile preview

bryophyllum pinnatum leaf extract

Development stage
Preclinical
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral, Topical
01

Overview

Bryophyllum pinnatum crude leaf extract is a botanical preparation derived from the leaves of the *Bryophyllum pinnatum* plant (synonym *Kalanchoe pinnata*), a perennial herb widely used in traditional medicine across India, Africa, and tropical America. The extract is rich in bioactive phytochemicals, including flavonoids, triterpenoids, and bufadienolides (such as bryophyllin A and C). Research, including studies on human cervical cancer cells, indicates that the extract possesses significant anticancer and anti-Human Papillomavirus (HPV) properties. Its mechanism of action in oncology involves the induction of apoptosis and the downregulation of the viral oncoproteins E6 and E7, which are essential for maintaining the malignant phenotype in HPV-positive cancers. Traditionally, the extract has also been employed for its antimicrobial, anti-inflammatory, and wound-healing effects, as well as for treating bowel diseases and various infections.

Other names
bryophyllum pinnata crude leaf extractKalanchoe pinnata leaf extractMiracle Leaf extractLife Plant extractCathedral Bells extractAir Plant extract
02

Targets

BAX (Apoptosis regulator BAX)CASP3 (Caspase-3)Human papillomavirus type 18 upstream regulatory region DNAFOS (Activator Protein 1)

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