bryostatin-22

Bryostatin-22 is a naturally occurring macrolide lactone belonging to the bryostatin family, originally isolated from the marine bryozoan *Bugula neritina*. Like its more widely studied relative, bryostatin-1, bryostatin-22 acts as a potent modulator of protein kinase C (PKC) by binding to the C1 regulatory domain of the enzyme. This binding typically induces a biphasic response characterized by an initial, transient activation of PKC followed by its rapid proteolytic degradation and subsequent downregulation. While bryostatin-1 has been extensively investigated in clinical trials for oncology, Alzheimer's disease, and HIV latency reversal, bryostatin-22 remains primarily a subject of preclinical research. It is frequently utilized in structure-activity relationship (SAR) studies to determine how specific substitutions on the bryostatin scaffold, such as the acetate group at the C20 position, influence binding affinity and biological potency across different PKC isoforms.

Other names

Bryostatin 22Bryostatin22Bryostatin-22