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BST204
- Development stage
- Phase 2
- Lead developer
- GC Wellbeing
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
BST204 is a botanical drug candidate developed by Green Cross Wellbeing for the treatment of cancer cachexia (cancer-induced muscle loss). It is a purified dry extract derived from *Panax ginseng* CA Meyer, enriched with ginsenosides Rg3 and Rh2 through enzymatic treatment and acid hydrolysis. The drug works through multiple mechanisms, primarily by activating the Akt/mTOR signaling pathway to prevent muscle atrophy and promote protein synthesis. Additionally, BST204 reduces systemic inflammatory responses and improves mitochondrial function. Preclinical evidence also suggests it may reduce chemotherapy-related fatigue and suppress cancer stem cell properties. It is currently in Phase 2 clinical trials.
- Other names
- fermented ginseng extractpurified ginseng dry extract
02
Targets
AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)mTOR (Mammalian target of rapamycin kinase)
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