Drug intelligence / Profile preview

BT-205

Development stage
Preclinical
Lead developer
Bridge Therapeutics
Modality
Small Molecules
Administration
Sublingual
01

Overview

**BT-205** is an investigational, sublingual fixed-dose analgesic combination developed by Bridge Therapeutics for moderate-to-severe chronic pain in opioid-experienced patients. It combines **buprenorphine**, a partial agonist at the mu-opioid receptor, with **meloxicam**, a nonsteroidal anti-inflammatory drug that inhibits cyclooxygenase enzymes, including COX-2. Bridge Therapeutics identifies BT-205 as a patented combination covered by U.S. Patent 8410092 and has also referred to the product as Bucam. ([bridgetherapeutics.com](https://bridgetherapeutics.com/))

Brand names
Bucam
Other names
buprenorphine + meloxicambuprenorphine-meloxicam
02

Targets

PTGS2 (Prostaglandin-Endoperoxide Synthase 2)MOR (Mu opioid receptor)

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