Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
BTPA-Ma
- Development stage
- Preclinical
- Lead developer
- Qilu Hospital of Shandong University
- Modality
- Small Molecules
01
Overview
BTPA-Ma is a mitochondria-targeted, triphenylamine-bridged bis-boronate small molecule designed for the dual-mode treatment of bladder cancer [P0657]. Developed by Shandong University and Qilu Hospital of Shandong University, BTPA-Ma exhibits context-dependent, bidirectional regulation of reactive oxygen species (ROS) [P0657]. Under white light irradiation, BTPA-Ma acts as a photosensitizer, triggering a massive ROS storm that causes mitochondrial rupture, endoplasmic reticulum stress via the PERK-EIF2α pathway, and immunogenic cell death (ICD) [P0657]. In the absence of light (dark conditions), BTPA-Ma functions as a ROS scavenger, gradually consuming intrinsic ROS in tumor cells, which upregulates PTEN and inhibits the PI3K-AKT proliferative pathway [P0657]. This dual functionality allows BTPA-Ma to suppress tumor growth and remodel the immunosuppressive tumor microenvironment [P0657].
- Other names
- triphenylamine-bridged bis-boronate probe
Beyond the preview
Go deeper on BTPA-Ma.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on BTPA-Ma.