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Bu Zhong Yi Qi Wan

Development stage: Unknown
Lead developer: Pingguang Pharmaceutical
Administration: Oral

Overview

Bu Zhong Yi Qi Wan is a classical multi-herb Traditional Chinese Medicine (TCM) formulation first documented in the 13th-century 'Treatise on the Spleen and Stomach' (Pí Wèi Lùn). It is primarily indicated for 'Spleen and Stomach Qi deficiency' and 'sinking of Middle Qi,' which manifest clinically as fatigue, poor appetite, and organ prolapse. The formula is composed of several herbal ingredients, including *Astragalus membranaceus* (Huang Qi), *Atractylodes macrocephala* (Bai Zhu), and *Codonopsis pilosula* (Dang Shen). Developed and marketed by companies such as Pingguang Pharmaceutical, it is an approved pharmaceutical product in China. Beyond its traditional uses, the formulation has been investigated in clinical settings for its potential to alleviate cancer-related fatigue and improve the quality of life for patients undergoing chemotherapy by modulating immune function and energy metabolism.

Brand names: Bu Zhong Yi Qi Wan
Other names: Tonify the Middle and Augment the Qi Pill补中益气丸Buzhong Yiqi WanBuzhong Yiqi Pill

Targets

IL1B (Interleukin-1 beta)NCOR1 (Nuclear receptor corepressor 1)AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)ESR1 (ERα)IL-6 (Interleukin 6)CASP3 (Caspase-3)NF-κB

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