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Bubali Cornu is the horn of the water buffalo (*Bubalus bubalis*), widely used in Traditional Chinese Medicine (TCM) as a substitute for the endangered rhinoceros horn. It is primarily indicated for clearing heat, cooling the blood, and detoxifying. Pharmacological studies indicate it possesses antipyretic, anti-inflammatory, and antiviral properties. Its therapeutic effects are attributed to a complex matrix of components, including keratins, collagen, amino acids, peptides, and small molecules like nicotinic acid and nucleosides. It is often used to treat high fever, viral infections (such as H1N1 influenza), and inflammatory conditions by modulating pathways like arachidonic acid metabolism and inhibiting pro-inflammatory mediators such as NOS2, TNF-α, and IL-1β.
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