Bubba Kush + cannabidiol

Bubba Kush + cannabidiol is a combination of the Indica-dominant cannabis strain Bubba Kush, which is characterized by high concentrations of delta-9-tetrahydrocannabinol (THC), and supplemental purified cannabidiol (CBD). This combination is primarily utilized in clinical research to investigate the "entourage effect" and the ability of CBD to modulate the pharmacological profile of THC. THC acts as a partial agonist at the G protein-coupled cannabinoid receptors CB1 and CB2, mediating analgesic, sedative, and psychoactive effects. CBD acts as a non-competitive negative allosteric modulator of the CB1 receptor, which may reduce the ceiling of THC's psychoactive impact, and as an agonist at the 5-HT1A serotonin receptor, potentially providing anxiolytic benefits. The combination is often studied for its potential to treat chronic pain, anxiety, and sleep disorders while minimizing the cognitive impairment and tachycardia associated with high-THC strains.

Other names

Bubba Kush and CBDTHC + CBD (Bubba Kush variant)