bucladesine

Bucladesine is a synthetic cyclic nucleotide derivative and stabilized analogue of endogenous cyclic adenosine monophosphate (cAMP). It is more lipophilic than cAMP and can permeate cell membranes, mimicking the physiological actions of cAMP. Bucladesine acts as a phosphodiesterase inhibitor and has been used as a vasodilator agent, cardiotonic drug, and in topical formulations for impaired wound healing. Its mechanism involves activation of protein kinases normally regulated by cAMP. Bucladesine was previously marketed in Japan (as Actosin ointment) for the treatment of skin ulcers but was later withdrawn despite favorable safety and efficacy profiles[1][3][5].

Brand names

Actosin

Other names

bucladesine6,2-O-dibutyryladenosine-3′,5′-cyclic monophosphatedibutyryl cyclic adenosine monophosphate