Drug intelligence / Profile preview

budesonide + azithromycin

Development stage
Phase 4
Lead developer
AstraZeneca
Modality
Small Molecules
Administration
Inhalation, Oral
01

Overview

Budesonide + azithromycin is a combination therapy used primarily for respiratory conditions, particularly in the treatment of Mycoplasma pneumonia. Budesonide is a corticosteroid that reduces inflammation, suppresses mucus secretion, and alleviates edema and spasms in the lungs. Azithromycin is a macrolide antibiotic effective against Mycoplasma pneumoniae infections. The combination has demonstrated enhanced therapeutic effectiveness, improved pulmonary function, diminished lung inflammation, reduced duration of fever, and faster resolution of symptoms compared to either medication alone. It effectively mitigates the overexpression of inflammatory factors such as C-reactive protein, TNF-α, and IL-6 without significantly increasing adverse reactions.

02

Targets

Bacterial 50S ribosomal subunitGR (Glucocorticoid receptor)

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