budesonide + carbamylated allergoid

Budesonide + carbamylated allergoid is a combination therapy consisting of budesonide, a potent synthetic corticosteroid with anti-inflammatory and immunosuppressive properties, and a carbamylated allergoid, which is an allergen extract modified by carbamylation to reduce its allergenicity while retaining immunogenicity. Budesonide acts primarily as a glucocorticoid receptor agonist, suppressing inflammation by inhibiting the activation of inflammatory cells (such as mast cells, eosinophils, and neutrophils) and blocking the release of pro-inflammatory mediators like histamine and cytokines[2][5]. Carbamylated allergoids are used in allergen-specific immunotherapy (often sublingual), aiming to induce immune tolerance to specific allergens with reduced risk of allergic reactions compared to native allergens. The combination has been studied for respiratory allergies such as birch pollen-induced mild persistent asthma; clinical data suggest that adding sublingual immunotherapy with carbamylated allergoids to low-dose inhaled budesonide can improve long-term seasonal asthma control while reducing corticosteroid exposure[7].