Drug intelligence / Profile preview

budesonide + ciclesonide

Development stage
Unknown
Lead developer
Azurity Pharmaceuticals
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
Administration
Inhalation
01

Overview

Budesonide + ciclesonide refers to a therapeutic regimen of inhaled corticosteroids (ICS) evaluated by the National Taiwan University Hospital to determine the clinical and genetic factors influencing treatment efficacy in children with asthma. Budesonide is a non-halogenated glucocorticoid with high local anti-inflammatory potency and minimal systemic effects. Ciclesonide is a next-generation ICS prodrug that is activated by esterases in the lung to its active metabolite, desisobutyryl-ciclesonide (des-CIC). Both agents function as agonists of the glucocorticoid receptor, leading to the suppression of pro-inflammatory gene expression and the reduction of airway inflammation and hyperresponsiveness. This specific combination was studied in a Phase 4 observational trial (NCT01444105) to optimize personalized asthma management in pediatric populations.

Brand names
DuasmaAlvesco
Other names
Budesonide/CisclesonideICS in Pediatric Asthma
02

Targets

GR (Glucocorticoid receptor)

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