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budigalimab + mFOLFOX6
- Development stage
- Preclinical
- Lead developer
- AbbVie
- Modality
- Nucleic Acid-Directed Small Molecules → Small Molecules, Monoclonal Antibodies → Antibody-Based Therapeutics, Covalent Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Intravenous
01
Overview
Budigalimab + mFOLFOX6 is a combination regimen consisting of budigalimab, a monoclonal antibody targeting programmed cell death protein 1 (PD-1), and mFOLFOX6, a modified FOLFOX6 chemotherapy protocol comprising oxaliplatin, leucovorin (folinic acid), and 5-fluorouracil. Budigalimab acts as an immune checkpoint inhibitor that enhances anti-tumor immune response by blocking PD-1 signaling, while mFOLFOX6 targets dividing cancer cells through cytotoxic chemotherapy. This combination is primarily investigated for its potential synergistic effects in the treatment of solid tumors, especially gastrointestinal cancers.
02
Targets
PDCD1 (Programmed cell death protein 1 receptor)CD274 (Programmed cell death protein 1 ligand 1)DNATS (Thymidylate synthase)
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